The objectives of Center for Studies of Host Response to Cancer Therapy are to create a self-sustaining, multidisciplinary research center at UAMS that examines the mechanisms of and prevention strategies for cancer-therapy-induced toxicity and side effects. This is the first center in its kind that is dedicated to proactively address how to minimize the impact of lasting cancer therapy-related toxicities. The focus of the center is on the mechanisms of side effects of cancer therapy and strategies to prevent such side effects is justified by the dramatic increase in the number of cancer survivors, currently exceeding 13 million in the US. Many cancer survivors are cured of their malignancy but suffer from treatment-related toxicities. While the importance of achieving cancer cure is duly recognized, comparatively little effort has been directed toward establishing the mechanisms of subsequent side effects of cancer therapy and at developing effective interventions to prevent them. The COBRE Center will promote the initiation and development or expansion of unique, innovative state-of-the-art biomedical and behavioral research centers at UAMS. Our key objectives are (1) to strengthen biomedical research infrastructure at UAMS through the establishment of a thematic multi-disciplinary center and (2) to enhance the ability of junior investigators to compete independently for complementary NIH individual research grant or other peer-reviewed support.