The research projects of Center for Studies of Host Response to Cancer Therapy are to geared to examine the mechanisms of and prevention strategies for cancer-therapy-induced toxicity and side effects. The focus of the center is on the mechanisms of side effects of cancer therapy and strategies to prevent such side effects is justified by the dramatic increase in the number of cancer survivors, currently exceeding 13 million in the US. Many cancer survivors are cured of their malignancy but suffer from treatment-related toxicities. While the importance of achieving cancer cure is duly recognized, comparatively little effort has been directed toward establishing the mechanisms of subsequent side effects of cancer therapy and at developing effective interventions to prevent them. The COBRE Center will promote the initiation and development or expansion of unique, innovative state-of-the-art biomedical and behavioral research at UAMS.